Life Science

Maugel DeStefano, The Richmond Group Complete KSQ Therapeutics Facility

KSQ Therapeutics at Four Maguire Road / Photos by Keitaro Yoshioka Photography

Lexington, MA – Maugel DeStefano Architects and The Richmond Group announced the completion of the 57,000sf research and development facility for KSQ Therapeutics at Four Maguire Road in Lexington.

Renovations included upgrades to the core and shell and a complete office and lab interior fit-out for KSQ Therapeutics, a clinical-stage company using the CRISPRomics discovery platform to systematically decode the entire genome to identify optimal gene targets for oncology and autoimmune disease. The new facility houses multiple laboratories, offices, conference rooms, a cafe, and outdoor amenity spaces.

KSQ Therapeutics collaboration spaces

Four Maguire Road is managed by The RMR Group, an alternative management firm that hired the design-build team in 2020 to reposition the property to attract a life science tenant. Building upgrades included all new mechanical and electrical infrastructure, utility services, lab utilities, and control areas for use and storage of hazardous materials. As a result of these upgrades, Four Maguire Road now has a certified LEED Core and Shell Silver rating. Additional project team members included AHA, DeSimone Consulting, Highpoint Engineering, Radner Design, Newmark, and Total Office Interiors.

Maugel DeStefano reimagined the building’s entrances with new lobby additions, storefront entrance systems, glass canopies, and cladding. Modern materials complement the existing exterior and add drama to the facade: Large-scale metal perforated panels frame entrances, soaring glass curtainwalls allow natural light to flood the interior, and faux copper patina panels and wood siding add color and interest. New outdoor amenity spaces feature seating areas, pedestrian paths, columnar way-finding lights, a covered bike rack, and a fire pit. The combination of architectural and landscape elements defines the entrances and is designed to create a welcoming approach.

Biophilic design principles inspired the interior layout and design. The building’s original exterior piers were replaced with storefront windows along the cafe to maximize exterior views and natural light to the first-floor cafe, board room, and open office area. Due to the increased depth and the geometry of the second floor, open office areas were located at exterior walls with conference rooms, huddle spaces, phone rooms, and support spaces located in the center of the building. Glazed walls and floating glass volumes at internal spaces allow natural light to filter through the office space into interior rooms.

KSQ Therapeutics

Interior finishes were also selected for their natural and organic feel. Wood strip ceilings, cork flooring, and a live-edge elm island top are designed to contribute warmth to the space. Veined quartz counters, carpet, and porcelain tiles were chosen for their organic patterns, and acoustical felt wall panels were designed in an organic wave pattern across the lobby accent wall.  An eclectic mix of light fixtures is also reminiscent of forms found in nature. In open office areas, amoeba-shaped light fixtures connect and flow across open-to-structure ceilings. Lights in boulder and helical shapes and mini-globe pendants, suspended in a wave pattern, take center stage in the cafe.

“The innovative interior design of KSQ Therapeutics not only symbolizes the life science research conducted at the facility, but also promotes employee well-being, health, and wellness,“ said Mark Pelletier, principal and science and advanced technology lead at Maugel DeStefano Architects. “We were honored to create this outstanding life science facility to support KSQ Therapeutics’ important work to treat a wide range of cancer and autoimmune disease.”

”KSQ is proud to call Four Maguire Road our new headquarters. A big thanks goes out to the team of experts who worked on the design and construction of this purpose built, state-of-the-art-facility. This flexible infrastructure will provide KSQ with the best opportunity to carry out our mission of bringing cures to patients,” says Wade Hicks, director of IT and lab operations and tenant design lead.